Quick and accurate validation of your Preparative Chromatography system.

Regular validation of Preparative HPLC pump flow rate is a critical task for ensuring the performance and repeatability of your system, as well as complying with regulatory requirements. Because few HPLC flowmeters have been available that are capable of covering the higher flow in preparative applications such as nanolipidic vaccine particle production, this has been an underexposed area of performance qualification. Herein we describe the validation of a positive displacement piston pump used in preparative liquid chromatography using a non-invasive, real-time flow meter. It has been demonstrated that this approach can reduce validation time in pumps by as much as 50%. In addition, the real-time digital data provided by the Prep Flowmeter will reduce human error and thus provide easy validation, all while increasing efficiency and reliability.

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