CHROMATOGRAPHY
Flow technique provides precise control over LNP formulation production
Lipid nanoparticles (LNPs) are a type of drug delivery system tat uses lipids to encapsulate and transport therapeutic agents, including drugs and genetic material, to targeted cells or tissues. They are increasingly recognised for their potential in overcoming challenges associated with conventional drug delivery, such as poor solubility, instability, and limited bioavailability.
Published in International Labmate – November 2025
Read on
La técnica de flujo proporciona un contyrol preciso sobre la producción de formulaciones LNP
Las nanoparticulas lipidicas (LNP) son un tipo de sistema de administración de fármacos que utiliza lipidos para encapsular y transportar agentes tera péuticos, incluidos fármacos y material genético, a c´lulas o tejidos especificos. Cada vez se reconoce más su potencial para superar los retos asociados a la administración convencional de fármacos, como la baja solubilidad, la inestabilidad y la biodisponibilidad limitada.
Published in tecnicas de LABORATORIO – October 2025
Read on
La technique Flow permet un contrôle précis de la production des formulations LNP
Les nanoparticules lipidiques (LNP) sont un type de systéme d'administration de médicaments qui untilise des lipides pour encapsular et transporter des agents thérapeutiques, notamment des médicaments et du matériel génétique, vers des cellules ou des tissus ciblés.
Published in La Gazette Du Laboratoire – October 2025
Read on
Improving Determination of Absolute Molecular Weight by SLS and MALS
Multi-Angle Static Light Scattering (MALS) is the preferred choice with scientists when determination of absolute molecular weight is a necessity. This technique not only has a solid basis in physics, it is also well understood, documented and widely used.
Read on
Effets de petites déviations du débit sur les résultats de la GPC/SEC
La GPC/SEC est sans aucun doute l’une des techniques les plus puissantes pour la caractérisation des polymères naturels et synthétiques. Sa flexibilité et le contenu informatif d’une seule mesure en font la technique de choix pour plusieurs objectifs différents, de la simple détermination de la distribution du poids moléculaire et de la polydispersité à l’analyse de structure la plus complexe ou à la distribution de la composition des copolymères.
Published in La Gazette Du Laboratoire – June 2025
Read on
Achieving accurate temperature-independent flow measurement
Accurate measurement of flow is a critical parameter in liquid chromatography systems where retention times and peak shape are often directly affected by flow rate. In such systems, even slight variations in flow can degrade reproducibility and data integrity. In HPLC and GPC applications, temperature variations are inevitable either due to heated column compartments, pump motors, or pre-heated solvent.
Read on
1% Abweichung, 40% Fehler: So htig ist Durchflussmessung
Kalibrierungen sind Pflicht für wiederholgenaue Ergebnisse. Doch gerade aufwendige Messreihen wie in der Gel-Permeations-Chromatographie dauern oft lange, sodass die tatsächliche Flussrate minimal abweichen kann. Welch enorme Folgen dies nach sich zieht, zeigt das folgende Beispiel.
Published in LaborPraxis – April 2025
Read on
Effects of small deviations in flow rate on GPC/SEC results
GPC/SEC is undoubtedly one of the most powerful techniques for the characterisation of natural and synthetic polymers. Its fexibility and the high information content available from just a single measurement, makes it the technique of choice for simple determination of molecular weight distribution and polydispersity of the most complex structure analysis or co-polymer composition distributions.
Published in Lab Asia – April 2025
Read on
El refractómetro differencial mejora la determinación del peso molecular por dispersión de la luz
El refractómetro differencial de Testa Analytical mejora la precisión de la determinación de dn/dc utilizando técnicas de dispersión de luz.
Published in Tecnicas de Laboratorio – April 2025
Read on
HPLC qualification for GMP-regulated labs
Qualification of HPLC Systems is one of the most common tasks in GMP-regulated laboratories. Several different regulatory guidelines and pharmacopeial standards offer frameworks for this, ranging from pure instructions to rigid quality standards to be checked and documented in regular intervals.
Read on
Effects of small deviations in flowrate on GPC/SEC results
GPC/SEC is undoubtedly one of the most powerful techniques for the characterisation of natural and synthetic polymers. Its fexibility and the high information content available from just a single measurement, makes it the technique of choice for simple determination of molecular weight distribution and polydispersity to the most complex structure analysis or co-polymer composition distribution.
Published in International Labmate – March 2025
Read on
Comparing volumetric and thermal flowmeters for assessing and validating liquid chromatography performance
Assessing and validating the performance of a pump serving HPLC, UHPLC, Ion Chromatography of GPC/SEC system is a crucial task in many laboratories these days.
Published in International Labmate – February 2025
Read on
Comparing volumetric and thermal flowmeters for assessing and validating liquid chromatography performance
Assessing and validating the performance of a pump serving HPLC, UHPLC, Ion Chromatography of GPC/SEC system is a crucial task in many laboratories these days.
Published in Lab Asia – February 2025
Read on
Comparaison des débitmètres volumétriques et thermiques pour l'évaluation et la validation des performances de la chromatographie liquide
L’évaluation et la validation des performances d’une pompe destinée aux systèmes HPLC, UHPLC, de chromatographie ionique ou de GPC/SEC est une tâche cruciale dans de nombreux laboratoires.
Published in La Gazette du Laboratoire – December 2024
Read on
Comparación de caudalímetros volumétricos y térmicos para evaluary y validar el rendimiento de la cromatografía líquida
Evaluar y validar el rendimiento de una bomba al servicio de un sistema de HPLC, UHPLC, cromatografía iónica o GPC/SEC es una tarea crucial en muchos laboratorios hoy en día. Para ello, la determinación precisa del caudal es una herramienta poderosa.
Published in Tecnicas de Laboratorio – December 2024
Read on
Testa Analytical's monitoring device used to validate preparative HPLC pump
Regular pump flow rate validation is crucial to ensuring pump performance, repeatability, and compliance with regulations. In this investigation, a non-invasive, real time flow monitoring device – the Prep Flowmeter was used to validate a Teledyne SSI M1 40ml single-headed, positive displacement piston pump commonly used for preparative liquid chromatography applications.
Published in Scientist Live – December 2024
Read on
Validation du gradient HPLC à l'aide de débitmètres non invasifs
La CLHP à gradient est un outil essentiel pour l’analyse d’échantillons contenant des composés de polarité variable. Son efficacité découle de la possibilité d’adapter à la fois la durée et la composition du gradient, ce qui permet de manipuler les temps de rétention des analytes.
Published in La Gazette du Laboratoire – October 2024
Read on
A time-saving pump validation method for preparative chromatography
Regular pump flow rate validation is a crucial tool in ensuring pump performance, repeatability, and compliance with regulations. In this investigation, a non-invasive, real time flow monitoring device – the Prep Flowmeter was used to validate a Teledyne SSI M1 40ml single-headed, positive displacement piston pump commonly used for preparative liquid chromatography applications.
Read on
© 2025 TESTA Analytical Solutions e.K. All rights reserved.